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Science Corner

September 7, 2007

I. Science and Service News Updates
II. Resources: Publications, Toolkits, Other Resources
III. Calls for Public Input
IV. Calls for Applications
V. Calendar of Events
VI. Funding Information
VII. Programmatic Funding Opportunities
VIII. Research Funding Opportunities (PAs and RFAs)

Print Version

Science and News Update
NIMH: Behavioral Interventions Effective for Preschoolers with ADHD
Two types of early interventions designed to reduce symptoms of attention deficit-hyperactivity disorder (ADHD) in preschoolers may be effective alternatives or additions to medication treatment, according to a recent NIMH-funded study. The study was published in the most recent quarterly edition of the journal School Psychology Review.
Science update: http://www.nimh.nih.gov/press/dupaul_adhdintervention.cfm
NIMH: Half of Children With Autism May be Diagnosable Soon After Their First Birthday
About half of children with autism spectrum disorders (ASD) can be diagnosed soon after their first birthday; others with the disorder may appear to develop normally until that age and then falter or regress during their second year, NIMH-funded researchers have discovered. Their study is the first to identify two such distinct patterns of illness onset by prospectively following the development of toddlers at risk for the disorders. The researchers hope to develop criteria for clinicians to use in diagnosing ASD’s in one-year-olds, since early intervention holds the best hope for a better outcome. The disorders are still rarely diagnosed before age 3. Findings are reported in the July 2007 issue of the Archives of General Psychiatry.
Science update: http://www.nimh.nih.gov/press/autismdiagnosis.cfm
NIMH: New Studies Search for Clues to Mental Illness in Gatekeepers of Gene Expression—Molecules called microRNAs may hold some answers
What goes awry in the brain to cause mental illness may ultimately be traced to glitches in genes - but not necessarily the parts of genes commonly suspected. Rather than the areas of genes that code for proteins, the secrets may be hidden in mysterious short sequences of genetic material called microRNAs. MicroRNAs help regulate gene expression — the turning on-and-off of genes to produce those proteins. Unraveling how this molecular machinery works is the focus of newly funded NIMH grants. Studies totaling $3 million per year over the next five years will seek to pinpoint how these “noncoding” parts of the genome increase vulnerability to schizophrenia, bipolar disorder, autism and other mental illnesses.
Science update: http://www.nimh.nih.gov/press/micrornas.cfm
NIMH: Gene Predicts Better Outcome as Cortex Normalizes in Teens with ADHD
Brain areas that control attention were thinnest in children with attention deficit hyperactivity disorder (ADHD) who carried a particular version of a gene in a NIMH study. However, the areas, on the right side of the brain's outer mantle, or cortex, normalized in thickness during the teen years in these children, coinciding with clinical improvement. Although this particular gene version increased risk for ADHD, it also predicted better clinical outcomes and higher IQ than two other common versions of the same gene in youth with ADHD. Results of the study are in the August issue of the Archives of General Psychiatry.
Press release: http://www.nimh.nih.gov/press/adhdcortex.cfm
NIMH: Parents' Diagnoses Help to Distinguish Childhood Bipolar Disorder from Severe Mood Dysregulation
The parents of children who have bipolar disorder are more likely to have bipolar disorder themselves than the parents of children who have severe mood dysregulation (SMD). This finding challenges the notion of some research that suggests SMD is a type of more broadly defined childhood bipolar disorder. The study by NIMH researchers was published in the August 2007 issue of the American Journal of Psychiatry.
Science update: http://www.nimh.nih.gov/press/brotman_bipolar_or_smd.cfm
NIMH: New Technique Pinpoints Crossroads of Depression in Rat Brain—Illuminates Brain Circuits at Work in Real Time
NIMH-funded scientists have developed a new high-speed technique for imaging brain activity and used it to pinpoint a circuit signal in rats that may be at the crossroads of depression — a possible "final common pathway" where different causes of, and treatments for, the disorder appear to converge. Activity in the circuit dampened when rats were in a depression-like state and revived after they were treated with antidepressants. The findings were reported online July 5, 2007 in Science Express.
Science update: http://www.nimh.nih.gov/press/depressioncrossroads.cfm
NICHD: Children Who Complete Intensive Early Childhood Program Show Gains in Adulthood—Greater College Attendance, Lower Crime and Depression
By the time they reached adulthood, graduates of an intensive early childhood education program for poor children showed higher educational attainment, lower rates of serious crime and incarceration, and lower rates of depressive symptoms than did non-participants in the program, reported researchers in a study funded in part by the National Institute of Child Health and Human Development (NICHD). The study appears in the August issue of the Archives of Pediatrics & Adolescent Medicine.
Press release: http://www.nih.gov/news/pr/aug2007/nichd-07.htm
NIH Funds New Program to Investigate Causes and Treatment of Autism
The National Institutes of Health (NIH) will intensify its efforts to find the causes of autism and identify new treatments for the disorder, through a new research program. The Autism Centers of Excellence (ACE) program represents a consolidation of two existing programs, the Studies to Advance Autism Research and Treatment and Collaborative Programs of Excellence in Autism programs into a single research effort. The NIH Institutes providing funding and expertise for the effort are the NICHD, the National Institute of Deafness and other Communication Disorders (NIDCD), the National Institute of Environmental Health Sciences (NIEHS), the NIMH and the National Institute of Neurological Disorders and Stroke (NINDS). Initially, five centers and one network will receive funding in 2007 to study autism spectrum disorders. Funding for a second set of ACE research programs will be announced in 2008.
Press release: http://www.nih.gov/news/pr/aug2007/nichd-02.htm
President’s Commission on Care for America’s Returning Wounded Warriors Issues Six Groundbreaking Patient and Family Centered Recommendations to Serve, Support and Simplify Care
Calling its recommendations a “bold blueprint for action” to serve, support and simplify the care for our injured service members, the President’s Commission on Care for America’s Returning Wounded Warriors approved six recommendations that make sweeping changes in the delivery of health care and services. The recommendations include the first major overhaul of the disability system in more than 50 years; creation of recovery plans with recovery coordinators; a new e-Benefits website; and guaranteeing care for PTSD from the VA for injured service members from Iraq and Afghanistan. The nine-member Commission called upon the White House and Congress to implement its recommendations as quickly as possible to ensure that those who have served in Iraq and Afghanistan are able to successfully transition back to civilian life or active duty service.
Press release: http://www.pccww.gov/docs/kit/press release final.doc
Report: http://www.pccww.gov/index.html
Resources: Publications, Toolkits, Other Resources
New on the NIMH Website
Interagency Autism Coordinating Committee November 17, 2006 Meeting Highlights
The highlights from the November 2006 Interagency Autism Coordinating Committee (IACC) is now available.
http://www.nimh.nih.gov/autismiacc/nov2006meeting.pdf
New on the NIMH Website
Interagency Autism Coordinating Committee November 17, 2006 Meeting Highlights
The highlights from the November 2006 Interagency Autism Coordinating Committee (IACC) is now available.
http://www.nimh.nih.gov/autismiacc/nov2006meeting.pdf
NIH Research Results for the Public: New Fact Sheets
Two new online fact sheets are available in NIH’s Research Results for the Public series.
Obsessive Compulsive Disorder
http://www.nih.gov/about/researchresultsforthepublic/OCD.pdf
Post-Traumatic Stress Disorder
http://www.nih.gov/about/researchresultsforthepublic/PTSD.pdf
NIH: Recent Newsletter Articles on Mental Health
Mental health topics covered in online NIH newsletters for the public:
NIH Record: The Person and Prison— Mental Illness Discussion Highlights Need For Change
http://nihrecord.od.nih.gov/newsletters/2007/07_27_2007/story2.htm
NIH Research Matters: Learning to Diagnose Autism Spectrum Disorders
http://www.nih.gov/news/research_matters/july2007/07162007autism.htm
NIH News in Health: Dealing With Trauma— Frightening Events Can Have Lasting Effects
http://newsinhealth.nih.gov/2007/August/docs/01features_01.htm
NIDA's Scientific Journal to become “Journal of Addiction Science & Clinical Practice”
The National Institute on Drug Abuse (NIDA) announced that it was changing the name of its scientific journal Perspectives to the Journal of Addiction Science & Clinical Practice, beginning with the November issue. The new title is designed to better reflect the journal's commitment to covering the exchange of ideas between researchers, clinicians, and others in the field of addiction science. NIDA will also increase the number of issues per year from once to twice a year, to accommodate the sizeable portfolio of scientific literature being produced in the growing field of drug abuse and addiction research.
http://www.nida.nih.gov/newsroom/07/NR8-01.html
NIAAA: Tips for Cutting Down on Drinking
Fact sheet from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) on reducing drinking.
http://pubs.niaaa.nih.gov/publications/Tips/tips.htm
NIA: New Age Page on Mourning Now Available
To help older people cope with grief, the National Institute on Aging (NIA) has added Mourning the Death of a Spouse to its Age Page series of easy-to-read brochures on health topics and related concerns. This new publication provides useful and practical advice on topics ranging from reactions to death to taking charge of life again. The brochure covers many facets of mourning and learning to live without a partner.
http://www.nia.nih.gov/HealthInformation/Publications/spouse.htm
New Reports from NIA
Growing Older in America: The Health and Retirement Study

This colorful compendium features analyses of data from the Health and Retirement Study (HRS), a national survey of Americans over age 50. The report describes the HRS's development and features and offers a snapshot of diverse research findings on older adults' health, work, economic circumstances, retirement, and family lives.
http://www.nia.nih.gov/ResearchInformation/HRS.htm .
2005-2006 Progress Report on Alzheimer's Disease: Journey to Discovery
The latest update on Alzheimer's disease (AD) research is now available from the NIA’s Alzheimer's Disease Education and Referral (ADEAR) Center. This 64-page report highlights recent advances in Alzheimer's disease (AD) research funded and conducted by the NIA and other components of the National Institutes of Health, describes the accelerating pace of discovery into the causes and processes of cognitive decline with age, and outlines the next steps in both research and prevention.
http://www.nia.nih.gov/Alzheimers/Publications/ADProgress2005_2006/
New Resources from SAMHSA
Integrating State Administrative Records to Manage Substance Abuse Treatment System Performance
This document provides both implementation considerations and technical guidance for developing integrated-data systems to monitor performance and improve service quality. Its purpose is to enhance states’ familiarity with using integrated data as a management tool.
http://www.kap.samhsa.gov/products/manuals/taps/index.htm
Homelessness and Mental Illness: Perspectives on Prevention
This special supplement to the Journal of Primary Prevention (JPP) highlights innovative strategies that are working to prevent and end homelessness among various high risk groups such as veterans, individuals with mental health and substance use issues, and vulnerable families. The result of a unique collaboration between the federal Center for Mental Health Services’ Homeless Programs Branch and JPP, the issue is provided free-of-charge by the publisher.
http://homeless.samhsa.gov/
SAMHSA: New Reports from the Office of Applied Studies
Gender Differences in Alcohol Use and Alcohol Dependence or Abuse - 2004 and 2005

Based on combined data from SAMHSA's 2004-2005 National Surveys on Drug Use and Health, the rate of past year alcohol dependence or abuse among persons aged 12 or older varied by level of alcohol use: 44.7 percent of past month heavy drinkers, 18.5 percent binge drinkers, 3.8 percent past month non-binge drinkers, and 1.3 percent of those who did not drink alcohol in the past month met the criteria for alcohol dependence or abuse in the past year. Males had higher rates than females for all measures of drinking in the past month: any alcohol use, binge drinking, and heavy alcohol use. Also, males were twice as likely as females to have met the criteria for alcohol dependence or abuse in the past year.
http://oas.samhsa.gov/2k7/AlcGender/AlcGender.cfm
Treatment Episode Data Se (TEDS) 1995-2005: National Admissions to Substance Abuse Treatment Services
This report provides information on the demographic and substance abuse characteristics of the 1.8 million annual admissions to treatment for abuse of alcohol and drugs in facilities that are licensed or certified by a state substance abuse agency and that report TEDS data.
http://www.dasis.samhsa.gov/teds05/TEDSAd2k5Index.htm
CMS Releases Promising Practices Reports for Persons with Autism Spectrum Disorders
The Centers for Medicare and Medicaid Services (CMS) announced the availability of three new promising practices reports that focus on Services for Individuals with Autism Spectrum Disorders.
California: Single Process for Diagnosis and Service Delivery
http://www.cms.hhs.gov/PromisingPractices/Downloads/CA-CollaborativeClinics6-7.pdf
Connecticut: Pilot Program for Young Adults with Autism Spectrum Disorders
http://www.cms.hhs.gov/PromisingPractices/Downloads/ConnecticutPromisingPractices8-3.pdf
Delaware: Supported Employment for Adults with Autism Spectrum Disorders
http://www.cms.hhs.gov/PromisingPractices/Downloads/DelawarePromisingPractices6-11.pdf
CDC: The Effectiveness of Universal School-Based Programs for the Prevention of Violent and Aggressive Behavior—A Report on Recommendations of the Task Force on Community Preventive Services
Universal school-based programs to reduce or prevent violent behavior are delivered to all children in classrooms in a grade or in a school. Similarly, programs targeted to schools in high-risk areas (defined by low socioeconomic status or high crime rates) are delivered to all children in a grade or school in those high-risk areas. During 2004--2006, the Task Force on Community Preventive Services (Task Force) conducted a systematic review of published scientific evidence concerning the effectiveness of these programs. The results of this review reported by the Centers for Disease Control and Prevention (CDC) provide strong evidence that universal school-based programs decrease rates of violence and aggressive behavior among school-aged children.
http://www.cdc.gov/mmwr/mmwr_rr.html?s_cid=mmwr_rr_e
AHRQ: New Review of Consumer-Oriented Strategies for Improving Health Benefit Design is Available
The Agency for Healthcare Research and Quality (AHRQ) has released an exploratory review of consumer directed health plans, tiered provider networks, and efforts to collect and disseminate information about provider quality. Increasingly, employers and health plans are experimenting with a set of consumer-driven strategies that are designed to empower consumers as knowledgeable decisionmakers regarding their health and their health care choices. The goals of the report were to provide a framework for assessing the likely effects of these three strategies and to review available published peer reviewed literature.
http://www.ahrq.gov/clinic/tp/consoritp.htm
Calls for Nominations
Calls for Public Input
Request for Information: NIH System to Support Biomedical and Behavioral Research and Peer Review
The NIH is seeking comments regarding NIH’s support of the biomedical and behavioral research, including peer review, with the goal of examining the current system to optimize its efficiency and effectiveness. The NIH is especially interested in creative suggestions, even if they involve radical changes to the current approach.
Deadline for comments: August 17, 2007.
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-07-074.html
From the Desk of Dr. Elias Zerhouni Newsletter:
http://www.nih.gov/about/director/newsletter/Summer2007.htm .
NCRR Seeks Input for New Strategic Plan 2009-2013
The National Center for Research Resources (NCRR) is seeking input as it develops a new Strategic Plan covering 2009–2013. NCRR is a research center that enables NIH-funded researchers across the country to translate basic discoveries into improved patient care. To ensure that NCRR continues to meet the needs of biomedical investigators, it is requesting input on six questions, which were published in the Federal Register on July 6, 2007.
Deadline for responses: August 24, 2007.
http://www.ncrr.nih.gov/Strategic_Plan/
2008 NIH Director's Council of Public Representatives Application Process Is Open
NIH is pleased to announce the open Application Process for the 2008 Director’s Council of Public Representatives (COPR) Roster. The COPR is designed (1) to obtain the broadest public input to the NIH Director on matters of public importance concerning biomedical research, and (2) to conduct the broadest outreach to increase the public’s understanding of the NIH and its programs. The COPR maintains a balanced composition of public members from the local, regional, and national levels with a range of professions and backgrounds, including but not limited to community leaders, patient advocates, health educators, media, medical and public health professionals, science administrators, and academicians who have a broad public perspective.
Applications due: Friday, September 14, 2007.
On Tuesday, August 21 at 3:00 pm, NIH will host a teleconference to present information on NIH and the COPR from the perspectives of the NIH staff and current Council members. To register, send an email with your name, affiliation, email, and telephone number to COPR1@palladianpartners.com or call the COPR Resource Staff at (301) 650-8660, ext. 131. You must register to participate in this teleconference. Upon registration, you will receive a confirmation email with information on how to participate in the teleconference.
http://copr.nih.gov/application.asp
Calls for Applications
Calendar of Events
Webcast: Child and Adolescent Refugee Mental Health
August 23, 2007 2:00-3:30 pm ET
This call is a part of SAMHSA’s National Child Traumatic Stress Network Culture and Trauma Teleconference Series.
http://www.nctsnet.org/nccts/nav.do?pid=ctr_top_train_tele_culsched
Teleconference: Best Practices Registry fro Suicide Prevention
August 27, 2007 2:30-4:00 pm EST
The next session in SAMHSA’s Suicide Prevention Resource Center (SPRC) Discussion Series will review the SPRC’s Best Practices Registry. The guest presenters will be Linda Langford of SPRC and Phil Rogers of the American Foundation for Suicide Prevention. http://www.sprc.org/featured_resources/trainingandevents/disc_series/index.asp
Health Observance: National Alcohol and Drug Addiction Recovery Month
September 2007
The Recovery Month observance highlights the societal benefits of substance abuse treatment, lauds the contributions of treatment providers and promotes the message that recovery from substance abuse in all its forms is possible. The observance also encourages citizens to take action to help expand and improve the availability of effective substance abuse treatment for those in need. This year's theme is "Saving Lives, Saving Dollars."
http://www.recoverymonth.gov
Health Observance: National Suicide Prevention Week
September 9-15, 2007
The goal of Suicide Prevention Week is to globally promote awareness and advocacy about suicide prevention. Significant efforts have been in place for many years to address the problem of suicide, but all those involved recognize that there is much work still to be done. This year’s theme, “Moving Forward with Education and Training,” acknowledges that efforts are underway and focuses attention on the critical issue of better preparing all those who are in a position to respond to those at risk for suicide.
http://www.healthfinder.gov/library/nho/nho.asp?year=2007#476
Third Annual NIH Director's Pioneer Award Symposium
Bethesda, Maryland, September 19, 2007
The event will feature research talks by the 2006 NIH Pioneer Award recipients; a poster session by 2004, 2005, and 2006 awardees and members of their labs; and announcement of the 2007 Pioneer awardees. The NIH Director's Pioneer Award program—a key component of the NIH Roadmap for Medical Research—supports exceptionally creative scientists who take highly innovative, and potentially transformative, approaches to major challenges in biomedical research. Attendance is free and no registration is required.
The event will also be available via videocast at: http://videocast.nih.gov
http://nihroadmap.nih.gov/pioneer/symposium2007/index.aspx
Funding Information
Request for Applications: National Anti Stigma Campaign State Implementation Grant
The SAMHSA, Center for Mental Health Services (CMHS), Resource Center to Address Discrimination and Stigma Associated with Mental Illness is accepting applications for National Anti-Stigma Campaign (NASC) State Implementation Grants. The purpose of these awards is to support and enhance the NASC through the development of State outreach and community-based efforts, mental health education and stigma reduction activities. SAMHSA’s National Anti-Stigma Campaign is a three-year, national public education campaign to educate the general public about mental health problems.
Application deadline is Friday, September 21, 2007
http://www.stopstigma.samhsa.gov/topics_materials/NASCgrants.htm
Finding U.S. Census Data for Grant Writing and Community Needs Assessment
The United States Census Bureau is the leading source of quality data about our nation's people and economy. While the Census Bureau is not a funding agency, it does provide information needed for grant proposals and Federal fund distributions. This tool kit is intended to provide a simple, easy approach to obtaining Census information for grant writing and community needs assessment.
http://www.census.gov/field/www/faith
Programmatic Funding Opportunities
Research Funding Opportunities (PAs and RFAs)
NIH Program Announcements (PAs)
[Full listing of NIH PAs at http://grants2.nih.gov/grants/guide/pa-files/index.html ]

Silvio O. Conte Centers for Interdisciplinary Research on Brain, Behavior, and Mental Health (P50)
http://grants.nih.gov/grants/guide/pa-files/PAR-07-430.html

Research on Alcohol-Related Public Policies such as Those Detailed in the Alcohol Policy Information System (R01)
http://grants.nih.gov/grants/guide/pa-files/PA-07-427.html

Research on Alcohol-Related Public Policies such as Those Detailed in the Alcohol Policy Information System (R21)
http://grants.nih.gov/grants/guide/pa-files/PA-07-428.html

Research on Alcohol-Related Public Policies such as Those Detailed in the Alcohol Policy Information System (R03)
http://grants.nih.gov/grants/guide/pa-files/PA-07-429.html

NIH Request for Applications (RFAs)
[Full listing of NIH RFAs at http://grants2.nih.gov/grants/guide/rfa-files/index.html ]

Basic and Translational Research Opportunities in the Social Neuroscience of Mental Health (R01)
http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-08-070.html

Genome-wide Association Studies in the Genes, Environment, and Health Initiative - Study Investigators (U01)
http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-07-012.html

Mental Retardation and Developmental Disabilities Research Centers 2008 (P30)
http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-07-012.html

The Outreach Partnership Program is a nationwide outreach initiative of the National Institute of Mental Health (NIMH) with support from the National Institute on Drug Abuse (NIDA) and in cooperation with the Substance Abuse and Mental Health Services Administration (SAMHSA) that enlists state and national organizations in a partnership to help close the gap between mental health research and clinical practice, inform the public about mental illnesses, and reduce the stigma and discrimination associated with mental illness. For more information on the NIMH Outreach Program please visit http://www.nimh.nih.gov/outreach/partners/ .

To subscribe to receive the Update every two weeks, go to: http://www.nimh.nih.gov/outreach/partners/updatelistserv.cfm

The information provided in the NIMH Update is intended for use by the Outreach Partners, National Partners, and their associates for the express purpose of exchanging information that may be useful in the development of state and local mental health outreach, information, education, and partnership programs.


 

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